Okay, don't expect to much...this isn't that big a deal (unless you are ~really~ a fan of the franchise)...but there's a game coming out called Super Mario Maker for Wii. It lets you create your own Mario levels using aspects from several Mario games.
http://www.amazon.com/Super-Mario-Maker-Wii-U/dp/B00KWFCSB2/ref=pd_rhf_ee_s_cp_1?ie=UTF8&refRID=08JCCZSFTSF4B86BKM6R
So the thought comes to mind, creating a level that uses P-balloons profusely (no clue if you can but assuming) and setting the characters as the various female characters (again, no clue if you can, but supposedly you can play as more than just Mario).
Nothing big, and tentative at best, but might be amusing to a few...
I've used custom mario level designers online but this looks like a really solid and effective solution. For me though, inflation in the games didn't do that much, unless it was Yoshi inflating. I always loved that especially in Super Mario Galaxy 2.
(come to think of it, I'd love that as an inflatable suit!)
(Not on here too often, replies might be slow.)